The commercialization of genetically modified organisms (GMOs) has sparked profound controversy concerning adequate approaches to risk regulation. Ethical discussions are an important characteristic of the resultant public debate. The ethical concerns regarding GMOs can be divided into two groups; that are intrinsic concerns and extrinsic concerns. Intrinsic concerns are the major reason that leads consumers to reject GMOs as a result of the process of genetic engineering that is regarded as unnatural, for example, interference with nature or playing God. A public conception that GMOs may have adverse effects on the environment and human health are regarded as extrinsic concerns. These include concerns expressed that GMO products place the farmer at a disadvantage. It is important to note that extrinsic concerns require major attention from both scientists and policy-makers as it is addressing these concerns that will contribute to greater safety assurance for the general public. It is recommended that both scientific investigation and regulatory oversight are needed, preferably on a case-by-case basis. However, a ban on all GM crops is not an appropriate way to solve the problem and can only result in denying the country use of a technology that can enhance production and provide a comparative advantage for exports. Apart from these concerns, the transparency of decision-making at all levels will lead to greater understanding, acceptance and proper use of GMOs for all stakeholders.